The Effect of Itraconazole on Aortic Histophatology in Hyperlipidemic Rabbits

Pourahmadi Mohammad¹, Feily Amir², Akbarnezhad Dorna³ and Kargar Jahromi Hossein⁴

1Department of Anatomy, Jahrom University of Medical Sciences, Jahrom, Iran. 2Department of Dermatology, Jahrom University of Medical Sciences, Jahrom, Iran. 3Department of Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran. 4Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.

ABSTRACT: Atherosclerosis is a chronic inflammatory disease and begins with the dysfunction of the endothelial layer of the vessels and continues to change the nature of the area beneath Intima and accumulation of lipoproteins in this area. Itraconazole, with a wide range of antifungal features, has important attributes such as anti-inflammatory activity, its inhibitory effect on the activity of 5-lipoxygenase and effect of the chemotaxis of T-Cell. 40 rabbits were divided into 4 equal groups. The first group were fed normal diet, second group was fed highcholesterol diet, the third group was fed with normal food and itraconazole drug and the fourth group was fed high-cholesterol diet and itraconazole and at the end of the twelfth week, the animals were anesthetized and aortic samples were taken, and information was studied after coloring. The mean size of the inner, middle and the adventitia of the aorta layers at the end of the twelfth week in the fourth and second groups were increased compared to control group, this increase was more obvious in the second group while it was reduced in the third group. In the second group at the end of the twelfth week a mass of foamy cells in the Intima layer was observed,while in the fourth group the amount was little and dispersed. Layers reduction of the aorta in the third group and also the fourth group compared to the second group can be caused by anti-inflammatory feature and antioxidant effects of itraconazole that avoid transient increase in blood fats after meal, which is highly atherogenic. Itraconazole drug affects the endothelial layer performance.

KEYWORDS: Itraconazole; Aorta; Histophatology; Hyperlipidemic; Rabbits Atherosclerosis

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