Volume 10, number 2

Formulation of Floating Tablet of Clarithromycin

S. Dehdari1, A. R. Dabirsiaghi1, A. R. Mortazavi2, K. Sajjadi1 and N. Adib3

1Azad University of Medicinal Sciences, School of Pharmacy, Pharmaceutics Department, Tehran, Iran. 2Shahid Beheshti University of Medicinal Sciences, School of Pharmacy, Pharmaceutics Department, Tehran, Iran. 3Food and Drug Lab Research Center, Ministry of Health, Tehran, Iran.

ABSTRACT: The aim of our study was to make a hydro dynamically balanced delivery system of clarithromycin, which would have the ability to float in the stomach with the desired in vitro release profile. Such a system would be suitable for localized action in the stomach in addition to prolonged systemic absorption for the treatment of H.pylori. Wet granulation technique was used to make various tablet formulations. The parameters which were studied included polymer (HPMC K4M) and sodium bicarbonate and fillers like Lactose and micro crystalline cellulose. The formulation with 41.6% clarithromycin, 20%HPMC K4M and 10% sodium bicarbonate gave a floating lag time of less than 3 minutes and a floating time of 12 hours and its release profile followed the Higuchi model.

KEYWORDS: Clarithromycin; Tablet; Floating; H.pylori

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Dehdari S, Dabirsiaghi A. R, Mortazavi A. R, Sajjadi K, Adib N. Formulation of Floating Tablet of Clarithromycin. Biosci Biotechnol Res Asia 2013;10(2)
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Dehdari S, Dabirsiaghi A. R, Mortazavi A. R, Sajjadi K, Adib N. Formulation of Floating Tablet of Clarithromycin. Biosci Biotechnol Res Asia 2013;10(2). Available from:https://www.biotech-asia.org/?p=10877

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