Volume 13, number 2
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In Vitro and In Vivo Antioxidant Property of Novel 2-Phenyl Quinazoline-4(3h)-One Derivatives

Praveen Kumar Kusuma1 and Girijasastry Vedula2*

1Medicinal Chemistry Research Lab, Vaagdevi College of Pharmacy, Kishanpura, Hanamkonda, Warangal-506001, Telangana State, India.

2Department of Pharmaceutical Sciences, College of Pharmacy, Andhra University, Visakhapatnam – 530003, Andhra Pradesh, India.

Corresponding Author E-mail: vgirijasastry@yahoo.co.in

 

DOI : http://dx.doi.org/10.13005/bbra/2141

ABSTRACT: Heterocyclic chemistry comprise as a minimum half of all organic chemistry research worldwide. In particular, heterocyclic structures form the basis of a lot of pharmaceutical, agrochemical and veterinary products. Quinazoline nucleus is a very attractive and useful scaffold in medicinal chemistry. The synthesized compounds were screened for in vitro and in-vivo antioxidant activity. The presence of antioxidants has been reported to protect lipids, blood and body fluids against the attack of reactive oxygen species like peroxide, superoxide and hydroxyl radicals. The presence of antioxidants in Test compounds (7a1, 7a2, 7a3, 7a4, 7a5, 7a6, 7a7, 7a8, 7b1, 7b2, 7b3, 7b4, 7b5, 7b6, 7b7 & 7b8) might be responsible for their observed antioxidant activity.

KEYWORDS: Quinazoline; Peroxide; Superoxide; Antioxidant activity

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Kusuma P. K, Vedula G. In Vitro and In Vivo Antioxidant Property of Novel 2-Phenyl Quinazoline-4(3h)-One Derivatives. Biosci Biotech Res Asia 2016;13(2).
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Kusuma P. K, Vedula G. In Vitro and In Vivo Antioxidant Property of Novel 2-Phenyl Quinazoline-4(3h)-One Derivatives. Biosci Biotech Res Asia 2016;13(2). Available from: https://www.biotech-asia.org/?p=11640

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