Preparation, Biological Activity and Characterisation of Novel Macroacyclic (N2O4 and N2O2) Schiff Base Ligands and Their Zn(II), Cd(II) and Hg(II) Complexes

Hamid Goudarziafshar and TaiebehTamoradi

Department of Chemistry, Faculty of Science, Ilam University, Ilam, Iran.

DOI : http://dx.doi.org/10.13005/bbra/2181

ABSTRACT: New macroacyclic N2O4(L1) and N2O2(L2) Schiff base ligands have been synthesized from 1,4-di-(4-fluoro-2-aminophenoxy)butane(DFAB)withsalicylaldehyde and 1,4-di-(4- fluoro-2-aminophenoxy)butane(DFAB)with anthracene-9-carbaldehyde, respectively. Zn(II), Cd(II) and Hg(II) complexes of the Schiff base ligands have also been prepared and all compounds have been characterised by IR, 1HNMR , 13CNMR spectroscopy and mass spectrometry. We are also especially interested in the antibacterial activity of these new complexes. The in vitro antibacterial activity of the metal ions, free ligands and their complexes were tested against the gram-positive bacteriaand gram-negative bacteriaby paper disc diffusion and minimum inhibitory concentration (MIC)methods. It is apparent the metal complexeshave good antibacterial activity but related free ligands and metal ions have not antibacterial activity.

KEYWORDS: Schiff base; Macroacyclic; Antibacterialactivity

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