Volume 13, number 2
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Efficacy of Non-Cytotoxic Doses of Some Medicinal Plant Extracts as Antibacterial and Anti-Biofilm Agents against Cariogenic Bacterium Streptococcus Mutans

Wael A. Elnaggar1*,Tarek Hosny Taha2, Nehal M El-Deeb3 and Hussam H. Arafat4,5

1Department of Health Sciences, Faculty of Pharmacy, Northern Border University, Rafha, KSA.

2Department of Environmental Biotechnology, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technology Applications (SRTA- CITY), New Borg El-Arab, Alexandria, Egypt.

3Department of Biopharmaceutical Product Research, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technology Applications (SRTA- CITY), New Borg El-Arab, Alexandria, Egypt.

4Department of Biology, Faculty of Science and Arts, Northern Border University, Rafha, KSA.

5Department of Botany and Microbiology, Faculty of Science, Minia University, Minia City- 61519, Egypt.

Corresponding Author E-mail: t_tarek7946@yahoo.com

DOI : http://dx.doi.org/10.13005/bbra/2163

ABSTRACT: Oral diseases are major health problems with dental caries and periodontal diseases among the most important preventable global infectious diseases. Increasing of refractory periodontal diseases is due to non-sensitivity of cariogenic bacteria to antibiotics, and the lack of new alternatives will be threat to danger imminent. This serious increase in the non-sensitivity of microbes to antibiotics may be opened to search for alternative approaches for exploring of new drugs with specific therapeutic activities. In this study cariogenic bacterium Streptococcus mutans strain ATCC 25175 was used as a test organism for evaluation the efficacy of water extracts of eight different medicinal plants as antibacterial and anti-biofilm agents. The best percentage of inhibition of these extracts against S. mutans strain ATCC 25175 was recorded as; Pomegranate peel˃ Clove˃ Coffeee˃ green tea. The cytotoxicity of the most potent extracts has been measured against fibroblast cells. Generally, the green tea extract was the safer extract followed by coffee, pomegranate peel and clove extracts. The recorded IC50 of the all used plant extracts on fibroblast cells ranged from 10-1.25%. with exception for green tea extract that didn't show IC50 even with the maximum used concentration. The potency of the three selected extracts to to inhibt the biofilm formation by the tested strain could be summarized by the following order: pomegranate peel˃ coffee˃ clove. Oral health influences the general quality of life and poor oral health is linked to chronic conditions and systemic diseases. Finally, give a recommendation for using some of these extracts to restrict the bacterial growth and reduction of the prevalence of periodontitis and cariogenic diseases.

KEYWORDS: Oral diseases;Medicinal plants;Cytotoxicity;Antibacterial;anti-biofilm agents

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Elnaggar W. A, Taha T. H, El-Deeb N. M, Arafat H. H. Efficacy of Non-Cytotoxic Doses of Some Medicinal Plant Extracts as Antibacterial and Anti-Biofilm Agents against Cariogenic Bacterium Streptococcus Mutans. Biosci Biotech Res Asia 2016;13(2)

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Elnaggar W. A, Taha T. H, El-Deeb N. M, Arafat H. H. Efficacy of Non-Cytotoxic Doses of Some Medicinal Plant Extracts as Antibacterial and Anti-Biofilm Agents against Cariogenic Bacterium Streptococcus Mutans. Biosci Biotech Res Asia 2016;13(2). Available from: https://www.biotech-asia.org/?p=14303

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