Volume 4, number 2
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Spectrophotometric method for the determination of Atorvastatin calcium in pharmaceutical formulations

S. VIJAYA SARADHI1*, G. DEVALA RAO2, P.S.K. BHARGAV3, B. RAMANA3, K.R. MANIKANTA3 and G. PAVAN KUMAR3

1Dept.of.Biotechnology, Koneru Lakshmaiah College of Engineering, Vaddeswaram - 522 502 (India).

2K.V.S.R. Siddhartha College of Pharmaceutical Sciences, (India).

3P.B.Siddhartha College of Arts and Science, Vijayawada - 520 010 (India).

ABSTRACT: A simple, sensitive and reproducible spectrophotometric method is developed for the determination of Atorvastatin calcium in bulk and in pharmaceutical formulations. This Method is based on the reaction of Atorvastatin calcium with Fe (III) of ferric chloride and Conc. hydrochloric acid to produce a yellow orange colored chromogen (λmax at 400 nm). Results of analysis were validated statistically and by recovery studies. This method is successfully employed for the determination of Atorvastatin calcium in various pharmaceutical preparations.

KEYWORDS: Atorvastatin calcium; Visible Spectrophotometric determination; Beer’s Law

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SARADHI S. V, RAO G. D, BHARGAV P. S. K, RAMANA B, MANIKANTA K. R, KUMAR G. P. Spectrophotometric method for the determination of Atorvastatin calcium in pharmaceutical formulations. Biosci Biotechnol Res Asia 2007;4(2)
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SARADHI S. V, RAO G. D, BHARGAV P. S. K, RAMANA B, MANIKANTA K. R, KUMAR G. P. Spectrophotometric method for the determination of Atorvastatin calcium in pharmaceutical formulations. Biosci Biotechnol Res Asia 2007;4(2). Available from: https://www.biotech-asia.org/?p=18573

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