Curcumin Reduce Sodium Fluoride-Induced Oxidative Stress in Rat Brain

Nagapuri Kiran Kumar, Mesram Nageshwar and Karnati Pratap Reddy  

Department of Zoology, Osmania University, Hyderabad, Telangana, India.

Corresponding Author E-mail: pratapkreddyou@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/2609

ABSTRACT: This study reports the ameliorative role of curcumin against sodium fluoride (NaF) induced oxidative stress in the brain of rats. The rats were divided into control, NaF (20 mg/kg), NaF+Curcumin (20mg/kg) and Curcumin (20mg/kg) groups respectively and treated at everyday interval for 60 consecutive days. Oxidative stress markers in the brain were measured at 60^th day. NaF treatment significantly increased LPO content, but decreased the level of GSH and activities of SOD, GPx, and CAT the brain of rats in comparison to the control rats. Oral administration of curcumin to fluoride exposed rats significantly reversed the content of lipid peroxidation, as well as enhanced the level of GSH and SOD, GPx and CAT activities to normal compared to NaF exposed rats. Thus, curcumin showed the potential to prevent sodium fluoride induced oxidative damage in the brain of rats and curcumin may be useful agents against neurodegeneration in the brain.

KEYWORDS: Curcumin; NaF; Neurodegeneration LPO;Oxidative Stress;

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