Volume 1, number 1
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Synthesis And Antimicrobial Activity Of Some New Thiazolidinones Containing N-Methyl Piperazine

H. S. Patel*, H. J. Mistry and H. D. Desai

Department of Chemistry, S. P. University, Vallabh Vidyanagar - 388 120, Gujarat India.

ABSTRACT: 4-(4’-sulphanilyl)-1-methyl piperazine (2) has been prepared by the reaction of N-acetyl sulphanilyl chloride (ASC) with 1-methyl piperazine followed by the hydrolysis of the product with ethanolic HCl. This compound (2) under go condensation with aromatic aldehydes to give the corresponding Schiff’s base (3a-h). The Schiff’s base (3a-h) on cyclocondensation reaction with thioglycolic acid gives 4-thiazolidinones. Biological screening of the prepared compounds has been carried out on some strains of bacteria.

KEYWORDS: Schiffs base; thiazolidinones; antimicrobial activity

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Patel H. S, Mistry H. J, Desai H. D. Synthesis And Antimicrobial Activity Of Some New Thiazolidinones Containing N-Methyl Piperazine. Biosci Biotechnol Res Asia 2003;1(1)
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Patel H. S, Mistry H. J, Desai H. D. Synthesis And Antimicrobial Activity Of Some New Thiazolidinones Containing N-Methyl Piperazine. Biosci Biotechnol Res Asia 2003;1(1). Available from: https://www.biotech-asia.org/?p=3376

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