Simultaneous spectrophotometeric determination of Ibuprofen and paracetamol by absorbance difference method

L.K. Omray¹, Shailendra Patil² and Asmita Gajbhiye³

¹Guru Ramdas Khalsa Institute of Science and Technology (Pharmacy), Jabalpur (India) ²Globus College of Pharmacy, Bangrasia, Bhopal (India) ³Department of Pharmaceutical Sciences, Dr. H.S. Gour Vishwavidyalaya, Sagar (India)

ABSTRACT: A spectrophotometeric method for the simultaneous and separate estimation of ibuprofen and paracetamol in binary tablet formulation has been developed. This method based on the estimation of one drug in presence of another drug by absorbance difference method. The ibuprofen and paracetamol solution were scanned over a range of 200 to 600 nm. In this method, two wavelengths 220nm and 231nm were chosen for ibuprofen and at these wavelengths the absorbance difference was almost zero while there was considerable absorbance difference in case of paracetamol, similarly. The two wavelengths 241nm and 255nm were chosen for paracetamol and at these two wavelengths, absorbance difference was almost zero while there was considerable absorbance difference in case of Ibuprofen. In the mixture of ibuprofen and paracetamol solution absorbance values of four wavelengths 220nm, 231nm, 241nm and 255nm were measured. The amount of ibuprofen was directly proportional to the absorbance difference between 241nm and 255 mm. Similarly, the amount of paracetamol was directly proportional to the absorbance difference between 220nm and 231 nm.

KEYWORDS: Ibuprofen; Paracetamol; Simultaneous determination; Absorbance difference

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