Volume 5, number 1
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Synthesis of benzothiazole selenato complexes and determination of its anti-tumor activity

B. Meenakshi2*, M. Bansal1, Shiv K. Gupta1 and Amit K. Das2

1R.V. Northland Institute, 18 Km on Ghaziabad-Bulandshahar G.T. Road, Dadri (Greater Noida Phase II), G. B. Nagar India.

2Krupanidhi College of Pharmacy, Koramangala, Bangaluru India.

Corresponding Author E-mail: mayank_pharma@rediffmail.com 

ABSTRACT: Different selenium complexes were synthesized using benzothaizole selenato ligand of Zn (II), Hg (II), Cd (II), Cu (II), and Ni (II). The derivatives M [Se (BTA)]2 (where M=Zn, Ni, Cu, Cd, Hg and BTA- benzothiazole) were prepared by the reaction of MCL2 with lithium arene selenato ligand of BTASe+Li. The compounds synthesised were identified and characterized by various method like melting point, thin layer chromatography, nuclear magnetic resonance, mass spectroscopy, atomic absorption spectroscopy, and screening for anti tumor activity was carried out of all the derivatives using Ehlirch asicites carcinoma (EAC) cells induced in albino mice. Out of those synthesized selenato metallic complexes Zn[Se(BTA)]2, Ni[Se(BTA)]2 were found to be potent anti -tumor since these compounds have shown increase in RBC, decrease in WBC, increase in life span, decrease in ascities fluid volume , increase in lymphocytes significantly.

KEYWORDS: Selenium complexes; Benzothiazole; Ehlirch asicites carcinoma (EAC)

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Meenakshi B, Bansal M, Gupta S. K, Das A. K, Synthesis of benzothiazole selenato complexes and determination of its anti-tumor activity. Biosci Biotechnol Res Asia 2008;5(1)
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Meenakshi B, Bansal M, Gupta S. K, Das A. K, Synthesis of benzothiazole selenato complexes and determination of its anti-tumor activity. Biosci Biotechnol Res Asia 2008;5(1). Available from: https://www.biotech-asia.org/?p=6837

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