Volume 5, number 1
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Anticancer Activity Of Pandanus Fascicularis Lam.

Senthil Kumar1*, R. Manivannan1, A. Balasubramaniam1 , R. Natarajan1 and B. Rajkapoor2

1Department of Pharmaceutical Chemistry, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengodu- 637 205 India.

2Department of Pharmacology, St Johns Pharmacy College, No 6, 9th Cross, 2nd Main, Vijayanagar 2nd Stage, Bangalore - 560 104 India.

ABSTRACT: Anticancer activity of ethanol extract of Pandanus fascicularis Lam. (EPF) was studied in mice. The anticancer activity of EPF was evaluated against Ehrlich Ascites Carcinoma (EAC) tumor model on dose dependent manner. The activity was assessed using survival time, average increase in body weight, hematological parameters and solid tumor volume. Oral administration of EPF increased the survival time and decreased the average body weight of the tumor bearing mice. After 14 days of inoculation, EPF is able to reverse the changes in the haemotological parameters, protein and PCV consequent to tumor inoculation. Oral administration of EPF was effective in reducing solid tumor mass development induced by EAC cells. The results shows EPF possess significant anticancer activity on dose dependent manner.

KEYWORDS: Ehrlich Ascites Carcinoma; Haematological parameters; Pandanus fascicularis

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Kumar R. S, Manivannan R, Balasubramaniam A, Natarajan R, Rajkapoor B. Anticancer activity of Pandanus fascicularis Lam. Biosci Biotechnol Res Asia 2008;5(1)
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Kumar P, Srivastava V, Kumar L. Development of new reversed-phase HPLC method for the determination of Mangiferin in Mangifera indica Linn. Biosci Biotechnol Res Asia 2008;5(1). Available from: https://www.biotech-asia.org/?p=6918

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