Volume 5, number 1
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Determination of Quetiapine Fumarate and Cilostazol in Bulk and Tablet by Uv-Spectrophotometry

R. A. Fursule*, D. K. Rupala, Md. Mujeeb Gulzar Khan, A. A. Shirkhedkar and S. J. Surana

Department of Pharmaceutical Chemistry, R.C. Patel College of Pharmacy, Karwand Naka, Shirpur, Dist: Dhule - 425 405 India

ABSTRACT: Simple, rapid, sensitive and accurate UV- Spectrophotometric methods have been developed for estimation of Quetiapine fumarate and Cilostazol in pharmaceutical formulation. In water, QTF showed absorbance maxima at 290 nm. In acetonitrile (30% v/v) CLZ showed maximum absorbance at 258 nm. Linearity was observed in the concentration range 6 - 54 μg/ml (r2= 0.9999) for QTF and 3 - 21 μg/mL (r2 = 0.9993) for CLZ. Amounts of drug estimated from the tablet formulations were in good agreement with label claim. Both the methods were validated statistically and by recovery studies.

KEYWORDS: UV- Spectrophotometry; Quetiapine fumarate; Cilostazol

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Fursule R. A, Rupala D. K, Khan M. M. G, Shirkhedkar A. A, Surana S. J. TDetermination of Quetiapine Fumarate and Cilostazol in Bulk and Tablet by Uv-Spectrophotometry. Biosci Biotechnol Res Asia 2008;5(1)
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Fursule R. A, Rupala D. K, Khan M. M. G, Shirkhedkar A. A, Surana S. J. TDetermination of Quetiapine Fumarate and Cilostazol in Bulk and Tablet by Uv-Spectrophotometry. Biosci Biotechnol Res Asia 2008;5(1) Available from: https://www.biotech-asia.org/?p=7022

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