Volume 5, number 1
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Simultaneous Spectrophotometric Estimation of Atorvastatin Calcium and Fenofibrate in Tablet Dosage Form

Atul A. Shirkhedkar* and Sanjay J. Surana

R. C. Patel College of Pharmacy, Karwand Naka, Shirpur, 425 405, Dist - Dhule India.

Corresponding Author E-mail: atul_shirkhedkar@yahoo.com 

ABSTRACT: Two analytical methods have been developed for simultaneous quantification of atorvastatin calcium and fenofibrate from combined pharmaceutical dosage form using spectrophotometer. Excellent simplicity, accuracy, precision and economy were achieved. The ‘method I’ is based upon ‘Q-absorbance’ whereas the ‘method II’ is based upon multicomponent mode of analysis of instrument. In methanol, atorvastatin calcium showed maximum absorbance at 245 nm and fenofibrate at 287 nm. Iso-absorptive point for both drugs was found to be 258 nm. Linearity lies in the concentration range 2 - 20 μg/ml for both drugs at their respective wavelength. The methods were validated statistically and by recovery studies.

KEYWORDS: Atorvastatin calcium; Fenofibrate; Spectrophotometry, Q-absorbance analysis

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Shirkhedkar A. A, Surana S. J, Simultaneous Spectrophotometric Estimation of Atorvastatin Calcium and Fenofibrate in Tablet Dosage Form. Biosci Biotechnol Res Asia 2008;5(1)
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Shirkhedkar A. A, Surana S. J, Simultaneous Spectrophotometric Estimation of Atorvastatin Calcium and Fenofibrate in Tablet Dosage Form. Biosci Biotechnol Res Asia 2008;5(1) Available from: https://www.biotech-asia.org/?p=7050

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