Effects of Carica Papaya on Lactate and Glutamate Dehydrogenase Activities in Selected Tissues of Alloxan Induced Diabetic Rabbits

Oloyede Omotade I.

Department of Biochemistry, University of Ado-Ekiti, Ekiti State Nigeria.

ABSTRACT: The activities of lactate and glutamate dehydrogenase in tissues like liver, kidney, stomach, small intestine and blood were investigated. Administration of aqueous extract of unripe pulp from Carica papaya resulted in a dose dependent inhibition of the activities of Lactate dehydrogenase. Significant reduction in Lactate dehydrogenase activity was observed (p<0.05) in the small intestine and kidney when compared with control values. However diabetic rabbits treated with aqueous extract (100mg/kg) showed increase in Lactate dehydrogenase activity when compared with diabetic untreated rabbits. In diabetic rabbits, Glutamate dehydrogenase activities reduced significantly (p<0.05) in serum, small intestine, stomach of animals treated with 100mg/kg body weight of the aqueous extract as opposed to increase in activity observed in the liver and kidney. The decreased level of Lactate dehydrogenase (LDH) and glutamate dehydrogenase (GDH) in the tissues of normal and diabetic rabbits could be related to enzymes in activation at both cellular and molecular levels. Since there is no corresponding increase in the serum. These results suggest the safe use and validity of the aqueous extract of unripe pulp from Carica papaya in the management of diabetes mellitus.

KEYWORDS: Lactate dehydrogenase; glutamate dehydrogenase; Alloxan and Diabetes

[ HTML Full Text]