Volume 5, number 2
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Hepatoprotective and Antioxidant Effects of Hygrophila Spinosa (K. Schum)Heine Acanthaceae Stem Extract

Ajay D. Kshirsagar and Purnima Ashok*

Department of Pharmacology K. L. E. Society’s College of Pharmacy, Bangalore - 560 010 India.

Corresponding Author E-mail: purnimaash06@gmail.com

ABSTRACT: Hygrophila Spinosa (K. Schum) Heine (syn. Asteracantha longifolia Nees, Acanthaceae) was widely used in the Indian systems of medicine for the treatment of various liver ailments. The hepatoprotective activity of the aqueous extract of the stem was studied on carbon tetrachloride induced liver toxicity in rats. The activity was assessed by monitoring the various liver function tests, viz. alanine transaminase, aspartate transaminase (AST), alkaline phosphatase (ALP), total protein and total bilirubin. Furthermore, hepatic tissues were subjected to histopathological studies. The stem extract was also studied for its in vitro antioxidant activity using ferric thiocyanate (FTC) and thiobarbituric acid (TBA) methods. The extract exhibited significant hepatoprotective and antioxidant activities.

KEYWORDS: Hepatoprotective; Antioxidant; Hygrophila spinnosa; Ferric thiocyanate; Superoxide radical

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Kshirsagar A. D, Ashok P. Fight Against the BruchHepatoprotective and Antioxidant Effects of Hygrophila Spinosa (K. Schum)Heine Acanthaceae Stem Extract. Biosci Biotechnol Res Asia 2008;5(2)
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Kshirsagar A. D, Ashok P. Fight Against the BruchHepatoprotective and Antioxidant Effects of Hygrophila Spinosa (K. Schum)Heine Acanthaceae Stem Extract. Biosci Biotechnol Res Asia 2008;5(2). Available from: https://www.biotech-asia.org/?p=7218

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