Volume 5, number 2
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Formulation,Optimization and Evaluation of Ocular Inserts of Ciprofloxacin Hydrochloride

Pankaj Kumar Sharma1, Arun Kumar1, Meenakshi Bajpai1, Monika Sachdeva1 and Pradeep Kumar2

1College of Pharmaceutical Sciences, Raj Kumar Goel Institute of Technology, Ghaziabad India.

2Department of Pharmaceutical Analysis, PES College of Pharmacy, Bangalore India.

Corresponding Author E_mail: pradeep_alpine@yahoo.co.in

ABSTRACT: Ocular inserts of Ciprofloxacin hydrochloride using Gelrite, HPMC, PVP and Carbopol were prepared by surface casting method and evaluated for uniformity of thickness, weight, drug content, surface pH, percent moisture absorption , percent moisture loss and in vitro release study. It can be concluded from the study that gelrite based ocular inserts of Ciprofloxacin hydrochloride shows constant release upto 6 hrs and can be effectively used for sustained topical ocular delivery.

KEYWORDS: Gelrite; HPMC; PVP; Carbopol; Ciprofloxacin hydrochloride; ocular insert

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Sharma P. K, Kumar A, Bajpai M, Sachdeva M, Kumar P. Formulation,Optimization and Evaluation of Ocular Inserts of Ciprofloxacin Hydrochloride. Biosci Biotechnol Res Asia 2008;5(2).
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Sharma P. K, Kumar A, Bajpai M, Sachdeva M, Kumar P. Formulation,Optimization and Evaluation of Ocular Inserts of Ciprofloxacin Hydrochloride. Biosci Biotechnol Res Asia 2008;5(2). Available from:

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