Volume 6, number 1
 PDF Downloads: 900

Formulation of Sustained Release Ambroxol Hydrochloride Matrix Tablets: Influence of Hydrophilic/Hydrophobic Polymers on The Release Rate and in Vitro Evaluation

V. Ravichandrian et al

VELS College of Pharmacy, Pallavaram, Chennai - 117 India.

ABSTRACT: Sustained release tablets of Ambroxol hydrochloride matrix tablets were developed using hydrophilic polymer HPMC K4M and Eudragit RSPO alone or combination with hydrophobic polymer Ethyl cellulose. The release study revealed that Eudragit RSPO or HPMC K4M was able to sustain the drug release up to 6hr and 8hr with ( 93.05±1.96, 96.12±1.74 ) respectively. While HPMC K4M or Eudragit RSPO with Ethyl cellulose sustained the drug release up to 12hrs with (95.64±1.02, 98.77±1.23). The in vitro release data was fit to Korsmeyer Peppas and the release mechanism was found to diffusion along with erosion and it is further confirmed by the SEM analysis. Hence the sustained release matrix tablet of Ambroxol hydrochloride attains therapeutic concentration in the blood plasma, leading to improved efficacy and better patient compliance.

KEYWORDS: Bronchitis; ambroxol hydrochloride; matrix tablets; HPMC K4M; Eudragit RSPO

Download this article as: 
Copy the following to cite this article:

Ravichandrian et al V. Formulation of Sustained Release Ambroxol Hydrochloride Matrix Tablets: Influence of Hydrophilic/Hydrophobic Polymers on The Release Rate and in Vitro Evaluation. Biosci Biotechnol Res Asia 2008;6(1)

Copy the following to cite this URL:

Ravichandrian et al V. Formulation of Sustained Release Ambroxol Hydrochloride Matrix Tablets: Influence of Hydrophilic/Hydrophobic Polymers on The Release Rate and in Vitro Evaluation. Biosci Biotechnol Res Asia 2008;6(1). Available from: https://www.biotech-asia.org/?p=8120

[ HTML Full Text]

Back to TOC