Anticancer and Anti-Inflammatory Activities of Extracts of Merremia Emerginata

Vasu Babu¹, K. Sujatha², A. S. Valli², K. J. P. Narayana³, B. H. Babu¹* and P. V. V. Satyanarayana¹

¹Department of Chemistry,Acharya Nagarjuna University, Nagarjunanagar- 522 510 India. ²Department of Biochemistry and Acharya Nagarjuna University, Nagarjunanagar- 522 510 India. ³Department of Microbiology, Acharya Nagarjuna University, Nagarjunanagar- 522 510 India.   Corresponding Author E-mail: harichem6678@gmail.com

ABSTRACT: Anticancer and Anti-inflammatory activities of Hexane(IA), Ethyl acetate(IB) and Methanol(IC) extracts of Merremia emerginata were studied by testing the inhibitory activity against cancer cell proliferation and pro-inflammatory cytokine TNF a. Three solvent extracts were tested on cell proliferation of different cancer cell lines like DU-145 (Human Prostate Carcinoma), KB (Mouth; Carcinoma), A549 (Human; Lung; Carcinoma) and MIA-PaCa2 (Human; Pancreas; Carcinoma). Ethyl acetate extract of M. emerginata was found to be showed inhibitory effect on KB, DU-145, A549 and MIA-PaCa2 cell lines followed by methanol and hexane extracts. The results showed that ethyl acetate extract has anti-inflammatory activity even at 5.986μg/ml and had a significant cytotoxic activity on different cells. The extracts of M. emerginata were screened to inhibit the TNF a secretion in LPS induced THP-1 cells. Among three extracts, ethyl acetate extract exhibited good activity against TNF ? production and the half maximal inhibitory concentration (IC50) was 5.9 μg/ml followed by IC.

KEYWORDS: Merremia emerginata; anticancer and anti-inflammatory activity

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