Volume 6, number 2
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Potent Antibacterial Activity of 1,3-Bis(N-Substituted Thioamido) Guanidines

Mahesh Kumar Gupta1, Surehdra N. Pandeya2, Ashok Kumar3 and Galal-M. Ziad4

1Prabhat Engineering College, Kanpur-Dehat - 209 304 India.

2Saroj Institute of Technology and Management, Lucknow - 226 002 India.

3-4Al-Margeb University, Al-Khums, Libya.

ABSTRACT: Bis-(N-p-chlorophenyl thioamido), bis-(N-phenyl thioamido) and bis-(N-tolyl thioamido) derivatives were tested for antibacterial activity against Staphylococcus aureus & Escherechia coli bacterial species. Antibacterial activity was measured by paper disc diffusion method. Inhibition zones indicated that 25 & 50 μg/ml of p-chloro derivative showed strong antibacterial activity against S. aureus and E. coli respectively. Synthesized compounds were also tested for antifungal activity against Candida albicans & Aspergillus niger fungal species. N-tolyl & N-phenyl derivatives showed good antifungal activity.

KEYWORDS: Antimicrobial activity; 1,3-bis(N-substituted thioamido)guanidines

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Gupta. M. K, Pandeya. S. N, Kumar. A, Ziad. G. M. K. Potent Antibacterial Activity of 1,3-Bis(N-Substituted Thioamido) Guanidines. Biosci Biotechnol Res Asia 2009;6(2)
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Gupta. M. K, Pandeya. S. N, Kumar. A, Ziad. G. M. K. Potent Antibacterial Activity of 1,3-Bis(N-Substituted Thioamido) Guanidines. Biosci Biotechnol Res Asia 2009;6(2). Available from: https://www.biotech-asia.org/?p=9130.

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