Spectrophotometric Determination of Desloratadine, Fexofenadine HCL, Etodolac, Moexipril HCL and Thiocolchicoside in Pure and Pharmaceutical Formulations  

Soad S. Abd El-Hay, Magda Y. El-Mammli and Abdalla A. Shalaby*

Department of Analytical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig - 44519 (Egypt).

ABSTRACT: A simple, sensitive and accurate spectrophotometric method was developed for determination of desloratadine (I), fexofenadine HCl (II), etodolac (III), moexipril HCl (IV) and thiocolchicoside (t). The method depends on oxidation of each of studied drugs with alkaline potassium permanganate where a green colour peaking at 607 nm is produced. The optimization of various experimental conditions was described. Beer’s law was obeyed in the range (2.5-25), (0.25-1.125), (0.1-1), (2.5-25) and (2.5-25) μg/ml for drugs (I), (II), (III), (IV) and (t) respectively. The molar absorptivity (e), sandell sensitivity, detection (LOD) and quantitation limits (LOQ) are calculated. The procedure was favorably applied for determination of certain pharmaceutical dosage forms containing the studied drugs. The obtained results were compared with the official and reported methods. There were no significant differences between the proposed and reference methods.

KEYWORDS: Desloratadine; Fexofenadine HCl; Etodolac; Moexipril HCl; Thiocolchicoside

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