Volume 8, number 1
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In vitro Anti-arthritic Activity of Methanolic Extract of Centella asiatica

Seema chaitanya Chippada, Sharan Volluri, Srinivasa rao Bammidi and Meena Vangalapati*

Centre of Biotechnology, Department of Chemical Engineering, A.U. College of Engineering (A), Andhra University, Visakhapatnam - 530 003 India.

Corresponding Author Email: meena_sekhar09@yahoo.co.in

ABSTRACT: Centella asiatica is a valuable medicinal herbaceous aromatic creeper which has been valued for centuries in ayurvedic medicine. Phytochemical analysis of Centella asiatica plant extracts revealed the presence of various biochemical compounds such as alkaloids, flavonoids, glycosides, triterpenoids and saponins etc. Our present work aims at evaluating the in-vitro anti-thritic effect of Centella asiatica at various concentrations. The inhibition of protein denaturation and membrane stabilisation were taken as a measure of the in vitro anti-arthritic activity. The maximum percentage inhibiton of protein denaturation and membrane stabilisation for C. asiatica extracts ware found to be 89.76 % and 94.97 % respectively at a dose of 2000 μg/ml. Therefore, our studies support the isolation and the use of active constituents from Centella asiatica in treating arthritis.

KEYWORDS: Anti-arthritic activity; Centella asiatica; Diclofenac sodium; Triterpenoids; Flavonoids

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Chippada S. C, Volluri S, Bammidi S. R, Vangalapati M. In vitro Anti-arthritic Activity of Methanolic Extract of Centella asiatica. Biosci Biotech Res Asia 2011;8(1)
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Chippada S. C, Volluri S, Bammidi S. R, Vangalapati M. In vitro Anti-arthritic Activity of Methanolic Extract of Centella asiatica. Biosci Biotech Res Asia 2011;8(1). Available from: https://www.biotech-asia.org/?p=9390

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