Anti-oxidant and Anti-hyperglycemic Properties of Methanolic Extracts of Medicinal Plants

K.S. Chandrashekharaiah^1* Menaka N Bolaki¹, Gupta Shivani Sanjay¹, Aanchal Bathija¹, V Krishna Murthy¹, M Narayanaswamy² and N Ramachandra Swamy³

1Department of Biotechnology, PES Institute of Technology, BSK III Stage, Bangalore-560 085, India.

2Department of Molecular Biology, Bangalore University, Bangalore - 560 056, India.

3Department of Biochemistry, Bangalore University, Bangalore - 5600 01, India.

DOI : http://dx.doi.org/10.13005/bbra/1171

ABSTRACT:

Total phenolic content, DPPH free radical scavenging activity and alpha amylae inhibitory potential was determined for three selected medicinal plants - Gymnema sylvestre, Terminalia arjuna and Tinospora cordifolia. The plant extracts were prepared with methanol. The total phenolic content of methonolic extracts of Gymnema sylvestre, Terminalia arjuna and Tinospora cordifolia. were 6.862, 20.862 and 7.987 mg GAE/g plant material respectively. All the three plants showed anti oxidant activities with their IC50 values were 6.862, 20.862 and 7.987 μg/ml compared to IC50 value of the standard L-Ascorbic acid, which was 11.59μg/ml. The extracts of Gymnema sylvestre showed ±-amylase inhibition. Thus the results provided evidence that among the studied plants, Gymnema sylvestre potential sources of natural antioxidant and antidiabetic activity.

KEYWORDS: Medicinal plants; total phenols; antioxidant activity; amylase inhibitory activity

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