Stem Cell-Based Therapy in Human Neurodegenerative Diseases

Esmaeel Ebrahimi¹, Seyed Ahmad Hosseini², Saeed Shirali^3* and Mostafa Cheshmposh¹

¹Department of Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ²Nutrition and Metabolic Diseases Research Center ,Ahvaz Jundishapur, University of Medical Sciences, Ahvaz, Iran. ³Hyperlipidemia Research Center, Department of Laboratory Sciences, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

DOI : http://dx.doi.org/10.13005/bbra/1600

ABSTRACT: Cell therapy is a procedure in which replace healthy cells to unhealthy and damaged cells. Due to lack of suitable methods for treatment of neurological diseases, patients have problems enormous. The lack of neurotransmitters and neurotrophic factors are main causes of these diseases. During the past decade, a variety of cells such as embryonic stem cells, fetal-derived neuronal cells, and induced pluripotent stem cells (iPSCs) have been used for compensate neurological deficits and treatment of these disorders in a variety of animal models. Several studies have been conducted to produce nerve cells by different types of stem cells. Although researchs in this field has progressed, their use is somewhat limited due to ethical problems and possible formation of teratoma. In this paper, we reviewed methods used of stem cells for the treatment of neurological disorders.

KEYWORDS: Cell Therapy; Neurological Diseases; Embryonic Stem Cells; Ipscs; Teratoma

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