Preparation of Controlled-release tablets containing Aceclofenac and its in vitro studies

S. Siddique¹, D. P. Chaterjee¹,  S.  Gupta², Aijaz Uddin³ and A. K. Chadoker¹

¹Department of Pharmaceutics, Rajiv Gandhi College of Pharmacy, Bhopal - 462 042 (India). ²Sagar Institute of Research and Technology, Bhopal - 462 041 (India). ³Department of Pharmacy, Dr. H.S. Gour University, Sagar (India)

ABSTRACT: The objective of this study was to develop uncoated HPMC matrix tablets, evaluating the relationship and influence of different content levels of microcystalline cellulose (MCC), starch and lactose, in order to achieve a zero-order release of Aceclofenac HPMC matrix tablets of Aceclofenac using microcrystalline cellulose (MCC), starch and lactose were prepared by wet granulation process. The USP paddle method was selected to perform the dissolution profiles carried out in 900 ml 0.1 N HCl, and phosphate buffer. There was no significant difference in drug release between the hydrophilic matrices when the HPMC concentration was modified in low percentage. Release kinetics of Aceclofenac from these swollen matrices was principally regulated by starch (17 percent) or lactose (17 percent), even in the presence of MCC. When starch (8.5 percent) and lactose (8.5 percent) were mixed at lower concentration in a ratio 1:1, MCC (5 percent or 7.5 percent) appeared to control the drug release. The release profile remained unchanged after three months storage of tablets. The best-fit release kinetics was achieved with the zero-order plot, followed by the Higuchi and first-order equations. The data obtained proved that the formulations are useful for a sustained release of Aceclofenac, due to the percentage released after 8 hours is nearly to 70 percent. The release of Aceclofenac was influenced by the presence of MCC, and by the different concentrations of starch and lactose. Compared to conventional tablets, release of the model drug from these HPMC matrix tablets was prolonged; as a result, an oral release dosage form to avoid the gastrointestinal adverse effects was achieved.

KEYWORDS: Aceclofenac; invitro studies; HPMC; MCC; USP

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