Influence of Polymorphisms -824 A/G Gene of Tumor Necrosis Factor Alpha on the Basic Economic Useful Traits of Cattle

Nikolai Nikolaevich Kochnev¹, Tatiana Igorevna Krytsyna¹, Anastasia¹, Maksimovna Smirnova¹ and Nikolay Seraphimovich Yudin²

¹Novosibirsk State Agrarian University, Russia, 630039, Novosibirsk, Dobroljubova Street, 160 ²Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Russia, 630090, Novosibirsk, Prospekt Lavrentyeva, 10.

ABSTRACT: Tumor necrosis factor alpha gene (TNF- ) codes protein which is a multifunctional cytokine and, along with the functions of the immune response, is involved in the morphogenesis and development of the fetus, plays an important role in the formation of mammary gland, stimulates the formation of prostaglandins and regulates appetite and lipid metabolism. The aim of the work is to study the genetic structure of herds of red steppe breed by polymorphism -824 A / G gene in the promoter of the TNF- gene, and to study possible associations of polymorphism with the main features of milk production, reproduction, growth and development of red steppe breed cattle. The sample of 148 animals the frequency of genotypes G/G, G/A and A /A, respectively, were 56%, 38% and 6% at a frequency of allele G - 75% and the allele A - 25%. Genotype frequencies distribution corresponded to Hardy-Weinberg equilibrium. Animals with genotype G / A significantly excelled in yield of milk for third lactation animals with the genotype G/G at 10%, as well as the number of milk fat and protein for the third lactation at 9 and 11%, respectively. A significant association of genotype G/A with the underweight calves at birth (p <0,05) was found. Animals with genotype G/G at the first insemination have age in 2 months lower than cows with genotype G/A (p <0,05). Duration of pregnancy in animals with genotype G/G was greater than that of heterozygous with G/A in 6.6 days (p <0,05).

KEYWORDS: TNF-a; polymorphism; cattle; milk yield; age at first insemination; pregnancy; birth weight

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