Analgesic activities of the medicinal plants of Wedelia trilobata, Wedelia biflora and Eclipta alba in standard experimental animal models

S. Sureshkumar¹*, S. Bhama¹, T. Siva Kumar ², M. J. N. Chandrasekar³ and R. Rajesh⁴ 

1J.K.K Nataraja College of Pharmacy, Komarapalayam - 638 183 (India) 2Nanda College of pharmacy, Erode – 638 052 (India) 3J.S.S College of Pharmacy, Ooty - 643 001 (India) 4Asst Manager, Quality Assurance, HUCLIN, Research Ltd, 4 th floor, Ticel Biopark, Chennai - 600 113 (India)

ABSTRACT: Comparative study on analgesic activity was carried using ethanol extracts in animal models. Wedelia trilobata (EEWT), Wedelia biflora (EEWB) and Eclipta alba (EEEA) was evaluated by acetic acid induced writhing method and hot plate assay to assess analgesic activity in mice. It was found that the extract caused an inhibition on the writhing response induced by acetic acid in a dose dependent manner. Dose of 500 mg/kg EEWT, EEWB, EEEA and Aspirin could block the writhing response by 49.17 %, 49.45, %, 55.23 % and 68.68 %( p<0.001) respectively. It was also indicated that the EEEA showed significant antinociceptive action in hot plate reaction time method in mice. This effect was comparable to that of standard drug morphine treated controls. The results reflects that analgesic effects and therapeutic efficacy of the extract on animal models which are comparable with those of standard drugs such as Aspirin and Morphine.

KEYWORDS: Wedelia trilobata, Wedelia biflora and Eclipta alba; Analgesic activity- Acetic acid induced

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