Spectrophotometric determination of serratiopeptidase and metronidazole in combined dosage forms

Deependra Singh¹, Swarnlata Saraf¹, V.K. Dixit² And Shailendra Saraf¹

¹Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (India) ²Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar (India)

ABSTRACT: Serratiopeptidase and metronidazole are the leading prescribing drugs by the physicians for various symptoms. Literature revealed that there is no combination formulation present in the market, which provokes the preparation of dual drug delivery system containing serratiopeptidase and metronidazole in a single dosage from. The estimation of Serratiopeptidase and metronidazole in a combined dosage form was developed, without prior separation. The method is the application of the derivative spectrophotometric method at zero crossing wavelengths. Serratiopeptidase is determined at 229 nm and metronidazole at 346.5 nm respectively. This method is simple, accurate and rapid and they require no preliminary separation and can therefore be used for routine analysis of both drugs in quality control laboratories

KEYWORDS: Serratiopeptidase; metronidazole; derivative spectrophotometry

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