Immunomodulatory Effects of Statins: Underlying Mechanisms and Experimental Evidence
N.N. Nwobodo
Department of Pharmacology and Therapeutics, Faculty of Clinical Medicine, Ebonyi State University, Abakaliki, Nigeria.
DOI : http://dx.doi.org/10.13005/bbra/1191
ABSTRACT:
Clinical and experimental evidence suggest that apart from cholesterol lowering, statins offer additional benefits via modulation of immune response. The immunological effects mediated by statins are due to their ability to partially inhibit a common denominator of multiple regulatory pathways. The modification of signal transduction proteins by isoprenoid intermediates generated by the mevalonate pathway is responsible for these effects. The inhibition of MHC class II upregulation by statins provides a rationale basis for therapeutically exploiting the pleiotropic effects of statins. Consequently, statin therapy may be considered an attractive approach in the treatment of autotoimmune diseases.
KEYWORDS: Experimental evidence; Immunomodulation; Isoprenoids; Mechanisms; Pleiotropic effects; Statins
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Copy the following to cite this article: Nwobodo N. N. Immunomodulatory Effects of Statins: Underlying Mechanisms and Experimental Evidence. Biosci Biotechnol Res Asia 2013;10(2) |
Copy the following to cite this URL: Nwobodo N. N. Immunomodulatory Effects of Statins: Underlying Mechanisms and Experimental Evidence. Biosci Biotechnol Res Asia 2013;10(2). Available from:https://www.biotech-asia.org/?p=10816 |