Analysis of Glycine Receptors Genetic Polymorphisms in Patients with Schizophrenia

Mehdipour Saeid*¹, KordiTamandani DorMohammad¹ and Rigi Esmat¹

Department of Biology, University of Sistan and Baluchestan, Zahedan, IR Iran.

DOI : http://dx.doi.org/10.13005/bbra/2366

ABSTRACT: Schizophrenia is a complex and debilitative mental disorder. There are some evidences indicating that there is a genetic linkage between Glycine receptors gene and schizophrenia incidence. This project evaluated the linkage between the three SNP of Glycine receptors gene in schizophrenia patients. A total of 113 patients including 16 women and 98 men were studied. The control group consisted of 117 healthy individuals (9 women and 108 men) with a mean age of 46.70+11.716 years, who was unrelated to SZC patients. We tried to select healthy individuals among people without any mental disorders. Results of all rs2229963، rs111946619 and rs78179793 SNPs showed that there is not any significant linkage between the incidence of this single nucleotide polymorphisms and risk of schizophrenia(rs2229963, P=0.934, rs111946619, P=0.780 and rs78179793, P=0.393) . We conclude that those SNPs are not suitable candidates to be considered as causes for schizophrenia incidence.

KEYWORDS: Schizophrenia; Glycine receptors gene; Polymorphism

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