Acute and Subchronic Toxicity Studies of Swertiamarin A lead Compound Isolated from Enicostemma Littorale .blume in wistar rats

G. Dhanavathy and Sylvia Jayakumar

¹Department of Biotechnology, School of Bioengineering,SRM University, Kattankulathur, Tamilnadu, India. ²Consultant Biostatistician, Benz academy, Chennai.

Corresponding Author E-mail:  dhanavathy.g@ktr.srmuniv.ac.in

DOI : http://dx.doi.org/10.13005/bbra/2456

ABSTRACT: Diabetes mellitus (DM) is a chronic disease caused by inherited or acquired deficiency in insulin secretion and/or by decreased responsiveness of the organs to insulin, is currently one of the most costly and burdensome diseases and affects about 5% of the global population with diabetic complications. Traditional herbal medicine has been widely used for disease treatment and is recognized as an interesting alternative to conventional medicine. Even natural herbal drugs are toxic above a certain concentration and hence it is essential to find out the effective concentration of the drug. Hence the amount of this swertiamarin to be administered in diabetic rats is an important factor in treatment of diabetes mellitus. Thus the assessment of effective dosage of the drug for fixing the dose is the most essential step in deciding the optimum activity of the drug. Inorder to achieve the optimum dosage, acute and subchronic toxicity studies of swertiamarin in Wistar rats was performed.

KEYWORDS: Toxicity; Swertiamarin; diabetes mellitus

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