Volume 14, number 1
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Cardiotoxicity and Hematoxicity of Sorafenib – Loaded  Nanoemulsion in Ehrlich Ascites Carcinoma - Bearing Mice

Mayson H. Alkhatib, Dunya A. Nori and Maryam A. Al-Ghamdi

Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Corresponding Author E-mail: mhalkhatib@kau.edu.sa

DOI : http://dx.doi.org/10.13005/bbra/2419

ABSTRACT: Sorafenib (SOR), a chemotherapeutic agent, is a multikinase inhibitor that has a cardiotoxic and hematoxic effect which could limit its application in cancer therapy. In the current study, SOR was incorporated into a nanoemulsion (NE) containing flaxseed oil (SOR-NE) and its antitumor effect was examined in Ehrlich ascites carcinoma (EAC)-bearing female Swiss Albino mice. Fifty mice were divided into five groups (n =10). Groups I and II served as untreated mice and untreated EAC-bearing mice, respectively, while groups III-V represented the EAC-mice administered orally with blank NE, SOR dissolved in Cremophor (SOR-Chremo) and SOR- NE, respectively. It has been found that SOR-NE group has lesser counts of white blood cells and decreased levels of cardiac enzymes and relatively normal heart tissue when compared to the SOR-Chremo group. Encapsulating SOR in NE has decreased its cytotoxicity on the heart and blood.

KEYWORDS: Chemotherapeutic agents; Cytotoxicity; Cardiac enzymes Flaxseed oil; Nanoparticle;

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Alkhatib M. H, Nori D. A, Al-Ghamdi M. A. Cardiotoxicity and Hematoxicity of Sorafenib – Loaded Nanoemulsion in Ehrlich Ascites Carcinoma - Bearing Mice. Biosci Biotech Res Asia 2017;14(1).
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Alkhatib M. H, Nori D. A, Al-Ghamdi M. A. Cardiotoxicity and Hematoxicity of Sorafenib – Loaded Nanoemulsion in Ehrlich Ascites Carcinoma - Bearing Mice. Biosci Biotech Res Asia 2017;14(1). Available from: https://www.biotech-asia.org/?p=22119

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