Volume 14, number 3
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In-Vitro Immunomodulatory Effect of Hydroalcoholic Leaves Extract of Avicennia officinalis

Sumithra M and Chitra V.

Srm College of Pharmacy, Srm University, Kattangulathur.

DOI : http://dx.doi.org/10.13005/bbra/2549

ABSTRACT: The stimulation or suppression of the immune response may modulate disease free state. Herbal medicine paved way for immunmodulation role in many mmunological disorder. The present study was  aimed to prove the traditional claim on the theimmunomodulatory activity ofAvicenniaofficinalisagainst autoimmune diseases. TheAvicenniaofficinalis leaves was authentified and coarsely powdered then extracted successively with  n-hexane,70% hydroalcohol followed by, ethylacetate. The phytoconstituentsofthe three extracts  were analysed . Finally, all were  subjected to (NBT) Nitrobluetetrazolium Assay, Candidacidal assay and Phagocytotic evaluation. The percentage yield and phytoconstituents of the extracts were determined. Among thethree extract, the ethanolic extract and Ethylacetateextractshowed effective immunomodulatory effect by their  suppression of leucocytes and neutrophils. The results of the present study proved the immunomodulatory effect of Avicenniaofficinalis and further studies  are essential to target this species against autoimmune diseases.

KEYWORDS: Candidacidal assay; Immunomodulation; Nitrobluetetrazolium Assay; Phagocytosis

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Sumithra M, Chitra V. In-Vitro Immunomodulatory Effect of Hydroalcoholic Leaves Extract of Avicennia officinalis. Biosci Biotech Res Asia 2017;14(3).
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Sumithra M, Chitra V. In-Vitro Immunomodulatory Effect of Hydroalcoholic Leaves Extract of Avicennia officinalis. Biosci Biotech Res Asia 2017;14(3). Available from: https://www.biotech-asia.org/?p=26889

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