Assessment of Genotoxic Effects of Nux Vomica as Homeopathic Drug on Mitotic Chromosomes of Vicia Faba

Sangeeta Dayal¹ and Harshal Kumar²

¹Department of Biotechnology, Monad University Hapur, India.

²National Bureau of Plant Genetic Resources; IARI PUSA; New Delhi, India.

Corresponding Author E-mail: harshal78617@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/2597

ABSTRACT: Extract of Nux vomica is used as homeopathic drug to cure various nervous disorders like mental emotion epilepsy, prolepses of the rectum, hydrophobia etc. The given dose of this drug is very small because of its poisonous effect in higher dose. In the present investigation we want to assess toxic effects of Nux vomica on somatic chromosomes of Vicia faba. Four concentrations 5%, 10%, 20% and 30%, were used for the treatment of root tips of test plant. There were number of abnormalities observed like stickiness at orientation of chromosomes, un-organization of chromosomes, fragmentation during separation of chromatids, multiple chromatin bridges formation etc. These types of aberrations were increased with increased concentration and duration of treatment of this drug.

KEYWORDS: Chromosomal Aberrations; Genotoxic; Homeopathic Drugs

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