HIstopathological Evaluation of A New Schistosomicidal Drug from Myrrh

Farid A. Badria¹ and Eman M. El-Nashar²

¹Pharmacognosy Department, Faculty of Pharmacy, Mansoura University.

²Mansoura and Histology and Cytology Department, Benha Faculty of Medicine, Zagazig University, (Egypt).

ABSTRACT: We reported early the biochemical and toxicological results of a new schistomicidal drug from myrrh (Commiphora molmol) (Badria et al.2001). In this study, a histological evaluation of myrrh preparation at therapeutic doses (250 and 500 mg/kg) on Swiss mice infected for 45 days with Schistosoma mansoni cercaria was examined. Liver sections were stained with H and E, and Masson’s trichome for detection of collagen fibers; Gorden and Sweet for reticular fibers. The results revealed a significant decrease in the number and size of granuloma in mice treated with myrrh preparation at 500 mg/kg. Also, at this dose there was a marked decrease in the intensity of collagen and reticular fibers and decrease of liver fibrosis. These results proved that myrrh preparation has both antifibrotic and schistosomicidal activity which may be explained as the excessive deposition of collagen in several types of lesions is known to undergo resorption when provocative causes are removed.

KEYWORDS: Histology; collagen fibers; reticular fibers; granuloma; myrrh

[ HTML Full Text]