Impact of Camel's Milk on Aluminum Chloride (Alcl₃) - Induced Toxicity in Rats

Hala A. Abdolhaleem¹, Magda Abd Elaziz², Mostafa M. Bashandy³ and Wafai Z. A. Mikhail^4* 

¹Dairy Department, Food Technology Research Institute, Agricultural Research Center, Ministry of Agriculture, Giza, Egypt

²Dairy Chemistry Department., Animal production Research Institute, Agricultural Research Center, Ministry of Agriculture, Dokki -Giza, Egypt

³Clinical Pathology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt

⁴Department of Natural Resources, Faculty of African Postgraduate Studies, Cairo University, Giza Egypt

Corresponding Author Email: wafai47@hotmail.com

DOI : http://dx.doi.org/10.13005/bbra/2782

ABSTRACT: The present study was carried out to evaluate the efficiency of camel's milk to ameliorate the toxicity of aluminum chloride AlCl₃ on some hematological parameters; hepatic,renal functions andlipids profile; as well ashistopathological alterations of some organs. Forty rats (8 / group) were divided into 5 treatment groups:Group1: Normal rats (negative control); Group2: AlCl₃induced toxicity rats (positive control); Group3: AlCl₃induced toxicity rats fed with raw camel milk; Group4: AlCl₃ induced toxicity rats fed with heat treated camel milk; andGroup5: AlCl₃ induced toxicity rats fed with sweet acidophilus camel milk.Rats were treatedby 5ml camel’s milk 10 min before the administration of 1 ml AlCl₃ (0.5 mg / kgbody weight); and had their respective doses daily for 30 successive days orally. AlCl₃ oral administration resulted in a significant decrease in red blood cells count (RBC's), significant increase in mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH); while hemoglobin (Hb),  hematocrite (Hct),  platelets(plt),  reticulocytes (Ret), mean corpuscular hemoglobin concentration (MCHC) did not revealed significant changes; the obtained anemia was macrocytic normochromic. The lipids profile; hepatic and renal functions showed non significant changes between different groups; however, histopathological examination showed variable alterations of varying severity in some organs; besides their response to camel's milk administration. Camel’s milk administration in groups 3, 4, 5 alleviated the toxic effect of AlCl₃ with variable degrees between different groups.

KEYWORDS: Aluminum Chloride; Camel's Milk; Kidney And Liver Functions; Lipids Profile; Macrocytic Normochromic Anemia; Red Blood Cells

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