Evaluation of Acute Oral Toxicity of a Polyherbal Liver Tonic for Poultry

Sunil Hajare¹, Ranjit Suresh Ingole², Sunidhi³, Ravikanth Kotagiri³ and Bhaskar Ganguly³*

¹Department of Veterinary Pharmacology and Toxicology, PGIVAS, Akola, India, 444104

²Department of Veterinary Pathology, PGIVAS, Akola, India, 444104

³Research and Development Unit, Ayurvet Limited, Baddi, India, 173205.

Corresponding Author E-mail : clinical01@ayurvet.in

DOI : http://dx.doi.org/10.13005/bbra/2813

ABSTRACT: The current study was designed to evaluate the acute oral toxicity potential of Superliv Gold liquid (M/s Ayurvet Limited, Baddi, India) according to OECD 423 guidelines. Superliv Gold liquid is a polyherbal hepatoprotective and hepatoregenerative liver tonic for poultry. Nine female Swiss albino mice were used for the study. Each animal served as its own control. Following the oral administration of the test substance, the animals were observed for manifestation of toxic effects and deaths. No toxic effects or mortalities were observed. The estimation of biochemical parameters (AST, ALT, ALP and creatinine) and histopathological studies also did not reveal any significant findings. Hence, Superliv Gold liquid was found to be safe for use.

KEYWORDS: Acute Oral Toxicity; Limit Test; OECD 423; Safety; Superliv Gold Liquid

[ HTML Full Text]