Volume 3, number 1
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Study Of Particle Size And Efficacy Of Transition Metal Complexes Of Mixed Ligands, Tolubutamide And Gliclazide, The Oral Antidiabetic Drugs

Arshi Siddiqui1*, S. A. Iqbal1, S. S. Khan2 and Meena Iqbal3

1Department of Chemistry, Saifia College of Science and Education, Bhopal - 462 001 (India). 2Department of Microbiology, Saifia College of Science and Education, Bhopal - 462 001 (India). 3Asian Biotechnology Research Centre, Bhopal - 462 001 (India)

ABSTRACT: The present study describes the particle size determination of mixed ligand complexes of tolbutamide (TBM), N-[(Butyl amino) carbonyl] – 4 methyl benzene sulfonamide (trade name, Rastinon) and gliclazide (GCZ) 1-(3-Azabicyclo [3,3,0] oct-3yl) – 3- (p-tolyl-sulfonyl) urea (trade name Diamicron) are oral hypoglycemics which were synthesized with copper, zinc, mercury, iron and cobalt and suitably isolated in pure powdered form. Yields are substantial. Stoichiometry suggests 1:1:1 (L1L2M) ratio between drugs and metal ion, (ternary complexes). Analytical data of these complexes agrees with the compositions C12H17N2O3S-Cu-C15H20N3O3S, C12H17N2O3S-Zn-C15H20N3O3S, C12H17N2O3S-Hg-C15H20N3O3S, C12H17N2O3S-Fe-G5-H20N3O3S.2H2O, C12H17N2O3S-Co-C15-H20N3O3S.2H2O.

KEYWORDS: Particle size; analysis; antidiabetic drugs; metal complexes

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Siddiqui A, Iqbal S. A, Khan S. S, Iqbal M. Study Of Particle Size And Efficacy Of Transition Metal Complexes Of Mixed Ligands, Tolubutamide And Gliclazide, The Oral Antidiabetic Drugs. Biosci Biotechnol Res Asia 2005;3(1)

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