Approach to Determine Crystalluria Influencing Factors in the Beni Mellal-Khenifra Area in Morocco, by Data Analysis

Mohamed Bouha^1,2, Malika Echajia^1*, Souad Mojahidi¹, Younes Aassem¹, Mustapha Oubenali¹ , Tarik El Ouafy³ , Mohamed Berkani² and Mohamed Mbarki¹.

¹Team of Analytical and Computational Chemistry, Nanotechnology and Environment, Faculty of Science and Technics, Sultan Moulay Slimane University, BeniMellal, Morocco.

²Laboratory of Spectrochemistry and Chemometrics, Science and Technologies Faculty, Sultan Moulay Slimane University, Beni-Mellal, Morocco.

³Team of Analytical and Computational Chemistry, Nanotechnology and Environment, Sultan Moulay Slimane University, Polydisciplinary Faculty, Khouribga, Morocco.

Corresponding Author E-mail:  m.echajia@uca.ac.ma

DOI : http://dx.doi.org/10.13005/bbra/2919

ABSTRACT: Urolithiasis presents an ascending prevalence in several countries around the world. The purpose of the present work is to achieve a fast and robust approach to the multiple factors influencing the chemical profile of human crystalluria and therefore in promoting the development of urinary calculi. From February to July 2018, 148 morning urine samples have been collected from 148 patients at the BeniMellal Regional Hospital Center in Morocco. An observation by Polarizing Light Microscopy allowed us to detect the chemical profile of crystalluria.A classification by the Principal Components Analysis (PCA) method has been applied to the individuals that are 148 crystalluria samples and to nine factors that are: ''gender'', ''age'', '' geographical area '', '' water quality'', ''water amount per day '', ''personal and family history'', ''urinary pH'', ''presence of crystals'' and ''chemical profile''. The first results of the principal components analysis (PCA) method shows that there are similarities between crystalluria samples and more or less strong correlations, between some of the nine factors that can influence crystalluria. The frequency of majority constituents in crystalluria is age dependent and oxalic-calcium is the frequent chemical species for both genders. The study of crystalluria would be an excellent laboratory test that brings many benefits for the diagnosis and management of renal pathologies of crystalline origin.One can conclude that urolithiasis is multifactorial, various factors may increase the risk of urinary stone formation.

KEYWORDS: Crystalluria; Chemical profile; polarizing light microscopy; principal components analysis; whewellite; weddellite

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