Emulgel Approach to Formulation Development: A Review

Brijesh Mahesh Patel, Ashwin Bhanudas Kuchekar and  Saish Rajendra Pawar

School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Pune-411038, India.

Corresponding Author E-mail:ashwinkuchekar@yahoo.in

DOI : http://dx.doi.org/10.13005/bbra/2931

ABSTRACT:

Topical drug delivery is the delivery of drugs anywhere in the body through skin, vaginal, ophthalmic and rectal routes. Drugs may be given for localized or systemic effects. Topical formulations with varying physicochemical properties, such as solid, semisolid, or liquid, can be developed. The topical system is created by preparing a drug emulsion and incorporating it into an emulgel. Emulgel is a thermodynamically stable formulation with low interfacial tension that is made by combining a surfactant and a co-surfactant and has several properties such as increased permeability and good thermodynamic stability. Emulgel has a dual control and a sustained release pattern. Emulgel improves bioavailability as well as patient compliance. The pH, viscosity, particle size, zeta potential, drug content, stability study, skin irritation test, and other properties of the prepared formulation are evaluated.

KEYWORDS: Co-surfactant; Emulgel; Gelling agent; Lipophilic; Surfactant

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