Apolipoprotein E Polymorphism and Alzheimer’s Risk in Kashmiri Population

Kamran Nissar^{1, 3}, Arshad Hussain² and Bashir Ahmad Ganai^3*

¹Department of Biochemistry, faculty of Biological Sciences, University of Kashmir, Srinagar, Jammu and Kashmir, India.

²Department. of Psychiatry, faculty of neurosciences, Institute of Mental health and Neurosciences, Srinagar, Jammu and Kashmir, India.

³Centre of Research for Development, faculty of multidisciplinary research centre, University of Kashmir, Srinagar, Jammu and Kashmir, India.

Corresponding Author E-mail: bbcganai@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/2950

ABSTRACT:

Background: Although the cause of Alzheimer's disease is unknown, most experts feel that the disease is caused by a combination of circumstances rather than a single cause. Age, gene polymorphism, diabetes, and other conditions are all risk factors for Alzheimer's disease. Given the importance of gene polymorphism in different diseases, we intended to find out the association of APOE gene polymorphism with Alzheimer's risk in the Kashmiri population. Method: Out of 300 patients who were referred to the memory clinic of the hospital, to evaluate the probable relation of APOE gene variation in Alzheimer's disease, we conducted the study on 59 clinically confirmed Alzheimer's patients and 52 age and ethnicity-matched healthy controls found in a community survey. Results: Our data revealed a statistically significant association of ε4 variant genotype of the  APOE gene with AD susceptibility in the Kashmiri population. Conclusions: The current study's findings provided insight into the role of APOE polymorphisms in Alzheimer's disease susceptibility. The identified susceptibility variant may become a marker genotype for AD.

KEYWORDS: Alzheimer's disease (AD); Apolipoprotein E (APOE); β-Amyloids; ε2, ε3 and ε4 Isoforms; Polymorphism

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