Electrospun Collagen Based Nanofibrous Mats for Wound Healing: An Integrative Review

Mugdha A. Kulkarni, Anoushka R. Gangal, Sameeha S. Khare, Harshal G. Mundada, Ashwini R. Gawade and Rohini R. Pujari*

School of Pharmacy, Dr. Vishwnath Karad MIT World Peace University, Kothrud, Pune- 411038, India, Maharashtra.

Corresponding Author E-mail: rohinirpujari@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/3006

ABSTRACT: Wound healing has always been an important issue that needs to be addressed, especially where second-and third-degree burns are considered. These types of burns extend to the dermis in second-degree burns and the tissues in third-degree burns and this process is extremely slow. Hypertrophic scarring and infection which are caused due to decreased immunity are some of the obstacles that need to be tackled. Recent studies show that fish collagen is useful in preventing infections due to its natural antimicrobial properties. Increased cellular respiration, exudate removal and retention of moisture are a few events that promote wound healing and these are aided by electrospun nanofibrous mats. Combining the properties of collagen into the nanofibrous mats in order to facilitate wound healing can potentially serve as an alternative to the current wound healing therapies. This article covers the various types of collagen that can be used with a focus on the synthetic polymeric blending into the collagen structures and its electrospinning process.

KEYWORDS: Burns; Collagen; Electrospinning; Nanofibrous Mats; Scaffolds; Wound Healing

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