Multipotential Secondary Metabolites from Nocardiopsis dassonovillei of Marine Actinomycetes and their In Silico studies

K. Dinesh Kumar¹, J. Vigneshwari², A. Gnanasekaran³, V. Selvamani¹ and P. K. Senthilkumar^1*

Department of Microbiology, Annamalai University, Annamalai Nagar, Tamil Nadu, India

Corresponding Author E-mail: drpks1980@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/3079

ABSTRACT: Actinomycetes are one of the important secondary metabolite producers. Researchers focused on the exclusive marine areas for isolation and identification of marine actinomycetes. The present study focused on the isolation and identification of Nocardiopsis dassonovillei (ON627850) from TS Pettai region. The potential strainTSP1 showed effective antibacterial activity against Haemophilus influenza. TSP1 isolates showed IC₅₀ value of 75.22 μg/ml effective antioxidant activity determined by DPPH assay. Cytotoxicity assay results were noted for the ethyl acetate extract of TSP1 screened against oral cancer cell lines (KB). The spectral characterization studies of UV, FT-IR and GC-MS results identified the compound 2,4-di-tert-butylphenol. The multi-potential 2,4-di-tert-butylphenol compound finally docked with KB cell lines protein for drug discoveries.

KEYWORDS: Actinomycetes; Cytotoxicity assay; DPPH, Drug; KB cell; Molecular Docking

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