Exploring the Role of Gentamicin in Cancer Treatment

Karthikeyan M^* and Praveen B M

Srinivas University, Mukka, Mangaluru, Karnataka, India.

Corresponding Author E-mail: karthikeyanpgt@gmail.com

ABSTRACT: Background: This comprehensive review explores the role of antibiotics in cancer development and treatment. The main mechanisms of cancer include abnormal growth and migration of cells with uncontrolled cell cycle, continuous self-renewal, and reproduction of cancer stem cells. Main Body: The review highlights the beneficial effects of cancer treatment with antibiotics, such as improving prognosis, reducing side effects, preventing or reducing wound infection, accelerating wound healing, and improving immune competence. However, the use of antibiotics can also significantly impact cancer treatments by causing microbial imbalance, decreasing immune capacity, and promoting inflammation. The review further discusses the potential of Gentamicin as a cancer treatment, its effects on sphingomyelin metabolism, and its potential as a sensitizing agent for cancer chemotherapy. Conclusion: The review concludes that while Gentamicin shows promise as a sensitizing agent, its application as an anticancer agent may be limited to specific drug combinations and cancer types. Future research is needed to further explore the relationship between mRNA and protein content in the context of Gentamicin treatment.

KEYWORDS: Antibiotic; Anticancer; Gentamicin; Sphingomyelin Metabolism

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