Development of Blumea lacera Gel Targeting Skin Disease

Arya Jayant Gijare , Kunal Jitendra Pardeshi, Aryan Mangesh Mandotand Swati Changdeo Jagdale^*

School of Health Sciences and Technology, Department of Pharmaceutical Sciences, Dr. Vishwanath Karad MIT World Peace University, MIT Campus, Kothrud, Pune,  MH, India.

Corresponding Author E-mail: jagdaleswati@rediffmail.com

DOI : http://dx.doi.org/10.13005/bbra/3246

ABSTRACT: Tribal people utilize Blumea lacera leaves for the treatment of skin injury. This plant has antibacterial and therapeutic qualities, according to ayurveda. Present study was aimed to formulate and evaluate an antimicrobial gel using Blumea lacera leaf extract for the treatment of skin diseases. Chemical identification tests and phytochemical screening were carried out to ascertain the presence of bio-active compounds. The extract efficacy was initially assessed through the agar plate method and diffusion test. The chemical identification tests revealed presence of alkaloids, flavonoids, tannins, and terpenoids in the leaf extract. It also revealed inhibitory effects against various microbial strains. Molecular docking studies matched with the antimicrobial compounds in docking to prove its activity. The docking scores of the nominated phytoconstituents (PubChem ID – 1548943, 6989) showed a higher interaction score. Polymer carbopol 940 in 1.12% exhibited good gelling property to the formulated gel of leaf extract powder. It has shown sustained effect for 8 hours. This comprehensive analysis enhances our understanding for the antimicrobial potential of the formulated gel, paving the way for future developments in plant-based antimicrobial agents targeting skin diseases.

KEYWORDS: Antimicrobial; Blumea lacera; Docking; Gel; Skin; Docking

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