Preparation and Characterization of Ciprofloxacin – Loaded Nanoparticles Using the Solvent Evaporation Technique: A Factorial Design

Vijay Sharma¹, Mitali Singh², Tribhuwan kumar Vashishtha¹ , Zaira Hussain ³ and Navneet Verma¹

¹Pharmacy Academy, IFTM University, Moradabad, Uttar Pradesh, India.

²Sahu Onkar Saran, School of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, India.

³Jamia Hamdard University, New Delhi, India.

Corresponding Author E- mail: vijaysrampur@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/3250

ABSTRACT: Evaporation of the solvent was utilized in this study to produce and characterize nanoparticles that were loaded with ciprofloxacin. Nine different batches of nanoparticles were manufactured, each of which included a different proportion of ethyl cellulose and polyvinyl alcohol. An investigation of the effects of E.C. and P.V.A. on one to nine formulations was carried out using a design that included 3² different factors. In order to produce the nanoparticles, E.C. and P.V.A. polymers were mixed in a variety of other combinations during the course of the manufacturing process. There were a number of elements that were analyzed in the description, including but not limited to zeta potential, morphology, drug content, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), differential scanning calorimetry (D.S.C.), and particle size. The outcomes of the study are extremely important, particularly the astounding yield of 88.33%. The result is indicative of the effectiveness of the manufacturing process, which emphasizes reduced waste and a production method that is well-monitored and provides unaltered quality and quantity in the end formulation. One of the most important discoveries made by the inquiry is that the greatest value of the percentage cumulative drug release was 63.4%. The outcome of this study reveals that the formulation can deliver a drug release that is both monitored and sustained over a prolonged time. It is essential to have this controlled release mechanism in place in order to maintain a constant concentration of the drug throughout the body. Formulation F7 is a promising contender for applications of ineffective and controlled drug delivery because of its exceptional characteristics, which include its small particle size, substantial drug content, high encapsulation efficiency, efficient drug loading, impressive yield, and significant cumulative drug release. In a nutshell, these characteristics position it as a promising contender. The findings shed light on the ways in which these features interact with one another to make F7 a viable alternative for drug delivery systems.

KEYWORDS: Ciprofloxacin HCl; Drug release kinetics; Drug delivery; Ethyl cellulose; Nanoparticles

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