Prevalence Around Inflammatory Caspases in Urinary Tract Infections, Review

Nisha¹, Deepak Chand Sharma ² , Ravi Datta Sharma¹ , Jinny Tomar^1*

¹Amity Institute of Biotechnology, Amity Institute of Integrative Science and Heath, Amity University Haryana 1, Gurugram (Manesar), india

²Department of Microbiology, Faculty of Science and Technology, Dr. Shakuntala Misra National Rehabilitation University 2, Lucknow, India

Corresponding Author E-mail: jinny.tomar@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/3308

ABSTRACT: Caspases are cysteinyl aspartate-specific proteases that play important roles in apoptosis, pyroptosis and cytokine maturation. Pyroptosis is a manifestation of inflammatory caspase mediated cell death induced by inflammatory caspases such as caspase-11, caspase 4, caspase 5 and caspase 1. These inflammatory caspases are involved in the inflammatory responses induced by these pathogens to control protozoan, viral, fungal and bacterial pathogen. This study aimed to understand the mechanism that involve different inflammatory caspases and their responses to urinary tract infections. By understanding the molecular pathways involved, we may be able to emphasize the specificity of inflammatory caspases. To acknowledge the physiological role of inflammatory caspases  in the pathological processes, the recognition of the domestic substrate of these inflammatory caspases, which ultimately leads to pyroptosis  must be recognized.

KEYWORDS: Inflammatory Caspases; NACHT leucin-rich repeat PYD protein 3 (NLRP3); Pathogenesis; Pyroptosis; Urinary tract Infection (UTI); Uropathogenic Escherichia coli (UPEC)

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