Volume 4, number 2
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Design and in-vitro evaluation of Lisinopril transdermal patches containing HPMC and PVP

B.G. Desai1, A.R. Annamalai2, B.M. Dinesh1 and K.S. Raghu1

1K. L. E. Society’s College of Pharmacy, II block, Rajajinagr, Bangalore - 560 010 (India) 2Anamalai University, Annamalai nagar, Chidambaram (India)

ABSTRACT: The Matrix type TDDS of Lisinopril were prepared using different ratios of Hydroxy propyl methyl cellulose (HPMC): Poly vinylpyrrolidone (PVP) (3:1, 2:3, 4:1, 1:2, 2:1, and 1:4) by solvent evaporation technique. Physicochemical parameters were characterized and dissolution studies of the formulated films were performed. In addition solubility studies at various pH, partition coefficient in octanol/water system, flux and enhancement ratio were also evaluated. In-vitro permeation studies were done using modified Franz diffusion cells through human cadaver skin utilizing 20%PEG 400 in normal saline. Permeation studies illustrated, 4% Hyaluronidase enzyme was a good enhancer. The prepared films were subjected to SEM and FTIR spectral analysis. Higuchi and Peppas model were used for optimizing the formulation.

KEYWORDS: Lisinopril; Transdermal Patches; PVP, HPMC; Permeability study, Chemical enhancers

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Desai B. G, Annamalai A. R, Dinesh B. M, Raghu K. S. Design and in-vitro evaluation of Lisinopril transdermal patches containing HPMC and PVP. Biosci Biotechnol Res Asia 2007;4(2)
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Dahiya R, Kaur R. Synthesis and anthelmintic potential of a novel series of 2-mercaptobenzimidazolopeptides. Biosci Biotechnol Res Asia 2007;4(2). Available from: https://www.biotech-asia.org/?p=5974

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