Volume 4, number 2
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An improved industrial process for synthesis of HMG-CoA reductase inhibitor Pitavastatin

S. R.Manne1, K. R. Bairy1, K. R. Chepyala1, K. K. Muppa1, R. T. Srinivasan, E. Sajja1 and S. R. Maramreddy2

1Department of Research and Development, MSN Laboratories Limited Survey No 317 and 323, Rudraram, Patancheru, Medak - 502 329 (India). 2Department of Chemistry, P.G. College of Science, Saifabad, Hyderabad (India).

ABSTRACT: An highly efficient cost effective, eco-friendly, commercially viable, convergent synthesis for the manufacturing of Pitavastatin, a HMG-CoA reductase inhibitor, has been developed.

KEYWORDS: Pitavastatin; HMG-CoA reductase inhibitor; E-alkene; syn-diol; Wittig-Horner-Emmons Coupling

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Manne S. R, Bairy K. R, Chepyala K. R, Muppa K. K, Srinivasan R. T, Sajja E, Maramreddy S. R. An improved industrial process for synthesis of HMG-CoA reductase inhibitor Pitavastatin. Biosci Biotechnol Res Asia 2007;4(2)
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Manne S. R, Bairy K. R, Chepyala K. R, Muppa K. K, Srinivasan R. T, Sajja E, Maramreddy S. R. An improved industrial process for synthesis of HMG-CoA reductase inhibitor Pitavastatin. Biosci Biotechnol Res Asia 2007;4(2). Available from: https://www.biotech-asia.org/?p=6031

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