Studies on the antifertility activities of the aqueous extract and aqueous suspension of Carrot (Daucus carota L.) seed powder through oral administration on Mice and Rat

P. Das¹*, M. Gupta² and U. K. Mazumdar²

¹Malhotra College, Badwai, Karond, Bhopal India.

²Department of Pharmaceutical Technology, Jadavpur University, Kolkata - 700 032 India.

ABSTRACT: The aqueous extract and aqueous suspension of Carrot ( Daucus carota L ) seed powder were tested through oral administration on adult mice and rats, individually to find out effect in their estrus cycle. There was significant change in estrus cycle in both kind of animals indicating the effectiveness of the oral administration of the afore mentioned two aqueous dosage forms. Prolonged oral administration of the aforementioned aqueous extract or suspension of seed powder did not show any adverse feature and / or abnormality of the organs like stomach, liver, kidney, uterus, and ovary of the treated animals on Histopathological examinations. The estimation of Haematological profile, Hepatorenal functions and metabolism of the untreated as well as treated animals were found in line with each other even after prolonged oral treatment with the aforementioned formulations. Thus, results of this study revealed that the aqueous extracts of D. carota L seeds and the aqueous suspension of seed powder show antisteroidogenic activity without any aparent adverse effect.

KEYWORDS: Carrot seed; antifertility; aqueous extract; antisteroidogenic activity; estrus cycle

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