Anti-secretory and anti-ulcer activity of Surasa, A poly herbal formulation in pylorus ligated (Shay) rat model

Shahabuddin Bahmani¹*, M. S. Harish¹, Majid Iqbal² and K. S. Rao²

¹Department of Pharmacology, Government College of Pharmacy Bangalore - 560 027 India.

²Department of Pharmaceutics, RRK Samithi’s College of Pharmacy, Naubad, Bidar -585 402 India.

ABSTRACT: Surasa is herbal formulation consisting of Phyllanthus embelica, Withania somnifera, Glycyrrhiza glabra, Cuminum cyminum, Eclipta alba and Shanka bhasma. In the present study anti-secretory and ulcer protective effects of Surasa was evaluated in pylorus-ligated rats’ model. Wistar rats weighing 180-200g were divided into seven groups of six animals each and were fasted for 36 hours before pylorus ligation, with water provided ad libitum. Ranitidine (50mg/kg.b.w) was administered to standard group. Test groups received Surasa at 3 dose levels: 137, 205, 274mg/kg.b.w for acute study and at 2 dose levels of 137 and 205 mg/kg for chronic study. For acute study treatments were administered orally one hour prior to pylorus ligation.3 For chronic study animals were treated for seven days. After the treatment, pylorus ligation was carried out under ether anesthesia. Animals were sacrificed four hours after pylorus ligation with overdose of anesthetic ether. Gastric juice was collected and volume, pH, free acidity and total acidity were measured. The stomachs were cut opened and inner surface was examined to determine ulcer index. In acute study Surasa, significantly (p< 0.05) reduced gastric secretions and ulcer score. Antisecrtroy and antiulcer activity of Surasa was very significant (p<0.01) with chronic treatment.

KEYWORDS: Herbal formulation; Gastric acid; gastric ulcers; Pylorus ligation

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